Obesity - The Gene Factor

[The Martian]

This is one of the few places where the US system makes more sense....

When a litre of water is a kilo? Not really, the metric system is logical and relative.

I mean a US pint does actually weigh a pound, whereas a UK one doesn't.

I didn't know that.

[Mr. Dazzle]

Watch out when buying a beer in America!

[Wreckless Rat]

This is one of the few places where the US system makes more sense....

When a litre of water is a kilo? Not really, the metric system is logical and relative.

I mean a US pint does actually weigh a pound, whereas a UK one doesn't.

US pint 473ml - 1.04lb
Uk pint 568ml - 1.25lb

Temp dependant obvs

[Mr. Dazzle]

Its supposed to be 16 fluid ounces...which would nominally be a pound wouldn't it.

Damned rude of reality to disagree.

[Horse]

unfortunately wrapped in other issues, like the chemicals running around your body.
... seems to bugger up my sleep even more, apparently it's serotonin, so by the time it catches up with me properly I'll be sitting feeling especially miserable.

I was thinking about this thread (full disclosure: I'm underheight for my weight, BMI was 26 last time I checked, but I've lost a few pounds since then) over the last couple of days.

We're all going to die of something, whether sudden 'accident' or by illness or, in a few cases, old age as the clockwork runs out.

Lifestyle choices may influence what illnesses we get. I suppose the irony is that if we eat 'healthily' and exercise we may be less likely to get diabetes or heart disease, etc - but live longer so get something else nasty instead.

So I was intrigued that you have noticed changes in sleep, as poor sleep is associated with many other conditions.

[Yambo]

Isn't obesity a huge problem for the NHS?

[Mr. Dazzle]

Isn't obesity a huge problem for the NHS?

I see what you did there.

[weeksy]

https://www.bbc.co.uk/news/health-56011979

Obesity: Appetite drug could mark 'new era' in tackling condition

A drug that suppresses appetite has led to some people losing more than a fifth of their body weight, a major international trial shows.

A weekly injection of the drug, semaglutide, was given alongside advice on diet and fitness.

The study, conducted on almost 2,000 people, showed an average 15kg weight loss during the 15-month trial.

Scientists said the results could mark a "new era" in treating obesity with even more therapies on the horizon.

Jan, from Kent, lost 28kg (four stone), equivalent to more than a fifth of her body weight.

"The drug changed my life and completely altered my approach to food," she said.

She said dieting had made her "miserable" but taking the drug was completely different as she was less hungry.

'Effortless'
However, now Jan has come off the trial her appetite has returned and she is putting weight back on.

She said: "It felt effortless losing weight while on the trial, but now it has gone back to feeling like a constant battle with food."

Semaglutide will already be familiar to some people who use it as a treatment for type 2 diabetes, but this trial looked at giving it at higher doses.

Tesco urged by investors to sell more healthy food
The drug works by hijacking the body's appetite levels and mimicking a hormone - called GLP1 - that is released after eating a filling meal.

The trial gave some people the drug and others a dummy injection, while both groups were given the lifestyle advice.

The results, published in the New England Journal of Medicine, showed people lost an average of 15kg on semaglutide compared with 2.6kg without.

However, 32% of people lost a fifth of their body weight with the drug, compared with fewer than 2% on the dummy treatment.

'New era'
Prof Rachel Batterham, from UCL and one of the UK researchers, told the BBC News website: "This is a game-changer in the amount of weight loss it causes.

"I have spent the last 20 years doing obesity research, up until now we've not had an effective treatment for obesity apart from bariatric surgery."

She said losing weight would reduce the risk of heart disease, diabetes and of severe Covid-19.

Semaglutide is being submitted to drugs regulators so cannot be routinely prescribed. However, Prof Batterham expects the drug would be used initially by specialist weight loss clinics rather than being widely available.

There were side-effects to the treatment including nausea, diarrhoea, vomiting, and constipation. And there are five-year studies taking place to see if weight loss can be sustained in the long term.

Prof Sir Stephen O'Rahilly, from the University of Cambridge, said: "The amount of weight loss achieved is greater than that seen with any licensed anti-obesity drug.

"This is the start of a new era for obesity drug development with the future direction being to achieve levels of weight loss comparable to semaglutide, while having fewer side-effects."

Dr Duane Mellor, a dietician and from Aston Medical School, said: "It is useful to have a potential option to help people lose weight, however we need to acknowledge that weight loss will still need lifestyle change, and that any medication or change in lifestyle can bring potential risks and side-effects.

"So, it is always wise to speak to a health professional before trying to lose weight."

[Yambo]

While there are medical conditions (some of which may well be psychological) that can cause obesity, imho it is mostly a lifestyle choice.

If you don't want to be overweight or obese then you won't be.

[Saga Lout]

When a litre of water is a kilo? Not really, the metric system is logical and relative.

But the Imperial system is better. I mean, it's obviously better, stands to reason, it's British. Innit.

One of the things that amuses me about the metric system is how they decided the unit of length. They based it on the size of the Earth, not the circumference of the Earth mind, but a quarter of the circumference of the Earth. Give or take a few miles.

[Mr. Dazzle]

Whereas a foot is based literally on a human foot. And they're really consistent aren't they?

[JackyJoll]

Yeah but a (real) gallon of water weighs 10 lb.

That’s decimal!

[lostboy]

When a litre of water is a kilo? Not really, the metric system is logical and relative.

But the Imperial system is better. I mean, it's obviously better, stands to reason, it's British. Innit.

One of the things that amuses me about the metric system is how they decided the unit of length. They based it on the size of the Earth, not the circumference of the Earth mind, but a quarter of the circumference of the Earth. Give or take a few miles.

You're not still bitter about them measuring from the North Pole down the Parisien meridian to the Equator rather than going through London are you? Get over it man!!

[Mr. Dazzle]

The 'official' definition of 1 pound is 0.45359237kg anyway...so everything is metric

The kilogram was redefined in 2019 so that ...the fixed numerical value of the Planck constant h is 6.62607015×10−34 when expressed in the unit J⋅s, which is equal to kg⋅m2⋅s−1, where the metre and the second are defined in terms of c and ... thus the kilogram is the mass of a body at rest whose equivalent energy equals the energy of a collection of photons whose frequencies sum to 1.356392489652×10^50 hertz...

I'm sure we all know how c and ΔνCs are worked out.

[Yambo]

. . . and the metre is currently defined as the length of the path travelled by light in a vacuum in 1/299 792 458 of a second.

Makes your 10000 metre rowing time pretty ridiculous now weeksy, eh!

[JackyJoll]

This is Gene Vincent’s birthday, talking of fat genes.

[JackyJoll]

. . . and the metre is currently defined as the length of the path travelled by light in a vacuum in 1/299 792 458 of a second.

Makes your 10000 metre rowing time pretty ridiculous now weeksy, eh!

Yes pick your opponents carefully.

And your cox.

[OBO]

Pah...less scoffing, and more physical hard work = no fat.
This method has been proven for centuries.

[Le_Fromage_Grande]

The 'official' definition of 1 pound is 0.45359237kg anyway...so everything is metric

The kilogram was redefined in 2019 so that ...the fixed numerical value of the Planck constant h is 6.62607015×10−34 when expressed in the unit J⋅s, which is equal to kg⋅m2⋅s−1, where the metre and the second are defined in terms of c and ... thus the kilogram is the mass of a body at rest whose equivalent energy equals the energy of a collection of photons whose frequencies sum to 1.356392489652×10^50 hertz...

I'm sure we all know how c and ΔνCs are worked out.

A kilogram isn't a measurement of weight, it's a measurement of mass

[OBO]

The 'official' definition of 1 pound is 0.45359237kg anyway...so everything is metric

The kilogram was redefined in 2019 so that ...the fixed numerical value of the Planck constant h is 6.62607015×10−34 when expressed in the unit J⋅s, which is equal to kg⋅m2⋅s−1, where the metre and the second are defined in terms of c and ... thus the kilogram is the mass of a body at rest whose equivalent energy equals the energy of a collection of photons whose frequencies sum to 1.356392489652×10^50 hertz...

I'm sure we all know how c and ΔνCs are worked out.

A kilogram isn't a measurement of weight, it's a measurement of mass

Then why is the stated Gross WEIGHT of my motorhome 3850 KG? ☺