Astrazeneca/Oxford vaccine approved

[demographic]

Before we get to slapping everyone on the back about the vaccine rollout this graph shows the percentage of the populations who are fully vaccinated, as in both shots.

Thats not to say that the vaccine rollout isn't going well mind, it seems to be proceeding at a fair pace and that data is a few days old but the jobs not done til its finished.

[wheelnut]

That fits with the UK plans of 12 week gap between jabs

[Mussels]

Before we get to slapping everyone on the back about the vaccine rollout this graph shows the percentage of the populations who are fully vaccinated, as in both shots.

Thats not to say that the vaccine rollout isn't going well mind, it seems to be proceeding at a fair pace and that data is a few days old but the jobs not done til its finished.

Claiming 2 injections means fully vaccinated against covid seems a little optimistic.

[weeksy]

Before we get to slapping everyone on the back about the vaccine rollout this graph shows the percentage of the populations who are fully vaccinated, as in both shots.

Thats not to say that the vaccine rollout isn't going well mind, it seems to be proceeding at a fair pace and that data is a few days old but the jobs not done til its finished.

That's never been the plan here, so is at this stage not important IMO.

[Kneerly Down]

Before we get to slapping everyone on the back about the vaccine rollout this graph shows the percentage of the populations who are fully vaccinated, as in both shots.

It's not like everyone is 'fully vaccinated' with 2 jabs, although obviously the recommendation is for 2 jabs to give best, long-lasting, effect.

If the first jab means those who've had it are not going to go to hospital and/or die it seems rather splitting hairs to judge on 2 jabs given at this point, seeing as the plan is to not have provided 2 jabs to most at this stage.

[Yambo]

It's an opportunity for point scoring, nothing more.

[irie]

Before we get to slapping everyone on the back about the vaccine rollout this graph shows the percentage of the populations who are fully vaccinated, as in both shots.

https://i.redd.it/97ekns4olbg61.png

Thats not to say that the vaccine rollout isn't going well mind, it seems to be proceeding at a fair pace and that data is a few days old but the jobs not done til its finished.

It has always been the strategy in the UK to concentrate on delivering first vaccinations with an extended time to delivering second vaccinations. This is because the first vaccinations virtually eliminate serious infections leading to hospitalisation, thereby protecting NHS hospitals and preventing them from being overwhelmed.

If you believe that second (aka booster) vaccinations should be provided instead of providing first vaccinations perhaps you would be kind enough to indicate why you believe that should be the case?

Thanks.

[demographic]

Before we get to slapping everyone on the back about the vaccine rollout this graph shows the percentage of the populations who are fully vaccinated, as in both shots.

https://i.redd.it/97ekns4olbg61.png

Thats not to say that the vaccine rollout isn't going well mind, it seems to be proceeding at a fair pace and that data is a few days old but the jobs not done til its finished.

It has always been the strategy in the UK to concentrate on delivering first vaccinations with an extended time to delivering second vaccinations. This is because the first vaccinations virtually eliminate serious infections leading to hospitalisation, thereby protecting NHS hospitals and preventing them from being overwhelmed.

If you believe that second (aka booster) vaccinations should be provided instead of providing first vaccinations perhaps you would be kind enough to indicate why you believe that should be the case?

Thanks.

Nope, I'm just pointing out that we have a fair way to go. We currently seem to have a few politicians briefing the press off the record about pubs opening and it all being over soon.
We've heard that a few times now and the UKs record of covid related deaths doesn't look at all good.
To me its just worth keeping an eye on.
You ok with that?

[Saga Lout]

Before we get to slapping everyone on the back about the vaccine rollout this graph shows the percentage of the populations who are fully vaccinated, as in both shots.

It's not like everyone is 'fully vaccinated' with 2 jabs, although obviously the recommendation is for 2 jabs to give best, long-lasting, effect.

If the first jab means those who've had it are not going to go to hospital and/or die it seems rather splitting hairs to judge on 2 jabs given at this point, seeing as the plan is to not have provided 2 jabs to most at this stage.

I think you could honestly claim to be fully vaccinated if you have had the complete treatment recommended by the vaccine producers. Of course, you won't be fully immunised but that's a different kettle of fish.

[irie]

To me its just worth keeping an eye on.
You ok with that?

Perfectly OK with that.

I would have thought that it was self evident that if ~15m have had their first vaccinations and ~0.5m have had their second vaccinations that would leave ~14.5m requiring second vaccinations, which is some way to go.

We'll trust you to keep an eye on it.

Thanks.

[irie]

Increasing the interval between doses from 6 to 12 weeks significantly improves immune response.

https://www.thelancet.com/journals/lanc ... 3/fulltext

Background

The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4–12 weeks. The planned roll-out in the UK will involve vaccinating people in high-risk categories with their first dose immediately, and delivering the second dose 12 weeks later. Here, we provide both a further prespecified pooled analysis of trials of ChAdOx1 nCoV-19 and exploratory analyses of the impact on immunogenicity and efficacy of extending the interval between priming and booster doses. In addition, we show the immunogenicity and protection afforded by the first dose, before a booster dose has been offered.

Findings

Between April 23 and Dec 6, 2020, 24 422 participants were recruited and vaccinated across the four studies, of whom 17 178 were included in the primary analysis (8597 receiving ChAdOx1 nCoV-19 and 8581 receiving control vaccine). The data cutoff for these analyses was Dec 7, 2020. 332 NAAT-positive infections met the primary endpoint of symptomatic infection more than 14 days after the second dose. Overall vaccine efficacy more than 14 days after the second dose was 66·7% (95% CI 57·4–74·0), with 84 (1·0%) cases in the 8597 participants in the ChAdOx1 nCoV-19 group and 248 (2·9%) in the 8581 participants in the control group. There were no hospital admissions for COVID-19 in the ChAdOx1 nCoV-19 group after the initial 21-day exclusion period, and 15 in the control group. 108 (0·9%) of 12 282 participants in the ChAdOx1 nCoV-19 group and 127 (1·1%) of 11 962 participants in the control group had serious adverse events. There were seven deaths considered unrelated to vaccination (two in the ChAdOx1 nCov-19 group and five in the control group), including one COVID-19-related death in one participant in the control group. Exploratory analyses showed that vaccine efficacy after a single standard dose of vaccine from day 22 to day 90 after vaccination was 76·0% (59·3–85·9). Our modelling analysis indicated that protection did not wane during this initial 3-month period. Similarly, antibody levels were maintained during this period with minimal waning by day 90 (geometric mean ratio [GMR] 0·66 [95% CI 0·59–0·74]). In the participants who received two standard doses, after the second dose, efficacy was higher in those with a longer prime-boost interval (vaccine efficacy 81·3% [95% CI 60·3–91·2] at ≥12 weeks) than in those with a short interval (vaccine efficacy 55·1% [33·0–69·9] at <6 weeks). These observations are supported by immunogenicity data that showed binding antibody responses more than two-fold higher after an interval of 12 or more weeks compared with an interval of less than 6 weeks in those who were aged 18–55 years (GMR 2·32 [2·01–2·68]).

Edit: significantly

[irie]

Now Germany, with it's appalling vaccination record, is trying to backtrack on what it earlier said about the Astrazeneca vaccine. But too late, they've shot themselves in the foot and the damage is done.

https://www.reuters.com/article/us-heal ... SKBN2AM0YA

The German government is reworking its strategy to vaccinate the nation against COVID-19 as its campaign, which has faltered due to a lack of supply, also faces public resistance to the shot from AstraZeneca Plc.

So rather than having an available and effective vaccine and perhaps a headache and some shivers or fever ...

Anecdotal reports that the AstraZeneca vaccine causes stronger side effects than other vaccines have been confirmed by Germany’s top vaccines agency, the Paul Ehrlich Institute.

It found that nearly a quarter of people receiving the AstraZeneca shot experienced flu-like symptoms, and around 15% experienced shivers or fever - more than side effects reported from the Pfizer or Moderna vaccines.

... they'd rather risk contracting Covid-19.

Good luck with that.

[DefTrap]

I'd be quite happy to camp outside the vaccine centre and wait for my turn (like those bellends do when they're after the new model iPhone). These vaccine-sceptics should just pipe down - nobody's forcing you and nobody wants to hear your effing chin-music.

My sister-in-law (60s) told me she's not having any vaccine - she can avoid getting covids by 'positive thinking' apparently. She's allowed an opinion. I know that because she told me twice, including when I initially didn't ask her at all if she was having a vaccine. She also sends 'prayers' on Facebook a lot, if this adds to the evidence of her analytical thinking.

[cheb]

I had the AstraZeneca jab on Saturday, last thing as there was one spare at the end of the day. As the other hero workers had had theirs I got this one.

Saturday night and most of Sunday through to early Monday morning saw me with flu like symptoms, and half awake hallucinations. By the time I got up at about half six on Monday I was back to was passes for normal.

The local health board is, AFAIK, leading the UK in the percentage vaccinated stakes, which is both nice, and a surprise. Usually they aren't that efficient at logistics.

[Noggin]

My SiL had the Pfizer one and was fine
My Bro got the AZ one yesterday and is currently down with man-covid!! LOL He has said that if the reaction to the vaccine is this bad he's bloody gla he's had it and won't get the real thing! LOL

[Horse]

I had Pfizer and was Pfine.

[Mussels]

I had the AstraZeneca jab on Saturday, last thing as there was one spare at the end of the day. As the other hero workers had had theirs I got this one.

Saturday night and most of Sunday through to early Monday morning saw me with flu like symptoms, and half awake hallucinations. By the time I got up at about half six on Monday I was back to was passes for normal.

The local health board is, AFAIK, leading the UK in the percentage vaccinated stakes, which is both nice, and a surprise. Usually they aren't that efficient at logistics.

Maybe they aren't that efficient at counting.

[irie]

Mrs irie gets another AZ jab tomorrow because it seems that for some reason her first AZ jab in January in a hospital wasn't recorded in the NHS database. Then I guess that in 12 weeks from tomorrow she'll get a supposedly second but actually third jab. Who knows wtf she'll end up like after three jabs!

[Saga Lout]

I had the AZ jab a month ago. No side effects at all.

[Skub]

I had Pfizer and was Pfine.

Me too,aside from a tender arm the day after. No biggie.