Pfizer vaccine approved

[Noggin]

... for the manufacturer to express concerns is a tad worrying, their profits not withstanding...

The bit in bold would make me question their 'concerns'. I get that maybe they are actually concerned but I've become so jaded with politicians and big companies that I am wary about everything they say!!

How could they make more profit from the same quantity of jabs? [ie 2 jobs given to fewer people, or 1 jab to twice as many]

Good point!! I'll go back to my crochet!!

[neilf]

Good point!! I'll go back to my crochet!!
[/quote]

The best ever response on a motorbike forum

[Noggin]

Good point!! I'll go back to my crochet!!

The best ever response on a motorbike forum

We've had about 10 cms of snow (at least) today and more last night - you aren't gonna get much about bikes from here for another few months!! LOL

[Supermofo]

The AZ vaccine is flooring more of our staff here. One of our directors is currently in hospital following theirs- probably unrelated, but just collapsed 2 days after.

That really doesn't sound good.

Neither does extending the gap between doses, sounds like we are going out on a limb as a country. But you got to worry where we'll be if we rush out first jabs and mess it up. It's all well and good crowing about charts where we are well ahead of vaccinating people if we get it wrong and waste it. Better surely to stick to the tested manufacturers tests

[Cousin Jack]

Pfizer jab today, zero ill effects do far, watch this space.

[Asian Boss]

All this because someone bummed a monkey in Haiti. Or was that AIDS?

[Yorick]

All this because someone bummed a monkey in Haiti. Or was that AIDS?

IIRC it was Iccy

[Wreckless Rat]

The AZ vaccine is flooring more of our staff here. One of our directors is currently in hospital following theirs- probably unrelated, but just collapsed 2 days after.

That really doesn't sound good.

Neither does extending the gap between doses, sounds like we are going out on a limb as a country. But you got to worry where we'll be if we rush out first jabs and mess it up. It's all well and good crowing about charts where we are well ahead of vaccinating people if we get it wrong and waste it. Better surely to stick to the tested manufacturers tests

It’s not like Boris has unilaterally made this decision a whim.

Andrew Pollard, the head of the Oxford Vaccine Group and chief investigator into the trial of this vaccine, said that extending the gap between vaccines made biological sense. “Generally, a longer gap between vaccine doses leads to a better immune response, with the second dose causing a better boost. (With HPV vaccine for girls, for example, the gap is a year and gives better responses than a one month gap.) From the Oxford vaccine trials, there is 70% protection after the first dose up to the second dose, and the immune response was about three times greater after the second dose when the second dose was delayed, comparing second dose after four weeks versus second dose after 2-3 months,” he told The BMJ, referring to the MHRA’s summary of product characteristics.11

“With the Pfizer vaccine, there are no published data comparing shorter and longer gaps between doses because all participants had the second dose at 3-4 weeks. However, the biology is straightforward and will be the same as with all vaccines . . . The immune system remembers the first dose and will respond whether the later dose is at three weeks or three months.”

In a statement the British Society for Immunology said, “Most immunologists would agree that delaying a second ‘booster’ dose of a protein antigen vaccine (such as the two approved covid-19 vaccines) by eight weeks would be unlikely to have a negative effect on the overall immune response post-boost. We also would not expect any specific safety issues to arise for the individual due to delaying the second dose, other than an increased potential risk of disease during the extended period due to lowered protection.”

[Mr. Dazzle]

The MMR gap is several years innit. In fact most childhood ones are spaced out by months and years aren't they?

[slowsider]

The MMR gap is several years innit. In fact most childhood ones are spaced out by months and years aren't they?

Presumably after validation. This current one has been tested at one interval and deployed at another.

[Mr. Dazzle]

My point is that the different gap for this Covid jab isn't an arbitrary political decision. Its got valid science behind it.
Nobody knows that it is better or worse, but there's a lot of valid evidence that it will be OK.

In times like these you can't wait for the approved 100% certainty route and everything has to be done on balance.

[Wreckless Rat]

Will be interesting once the uk is vaccinated - and France is still trying to bumble its way out of its current situation of doing fuck all, and having a population who don’t trust their Drs enough to take the vaccine, whether the UK will have the balls to return the favour and ban all French from the UK without a test + isolation etc. I do hope so.

[weeksy]

Will be interesting once the uk is vaccinated - and France is still trying to bumble its way out of its current situation of doing fuck all, and having a population who don’t trust their Drs enough to take the vaccine, whether the UK will have the balls to return the favour and ban all French from the UK without a test + isolation etc. I do hope so.

It's Portimao that's my thoughts as you can imagine. Be great if the UK does well with vaccination, but sod all use to me if Portugal is a shit show along with south America as we won't be allowed to fly there

[Supermofo]

The AZ vaccine is flooring more of our staff here. One of our directors is currently in hospital following theirs- probably unrelated, but just collapsed 2 days after.

That really doesn't sound good.

Neither does extending the gap between doses, sounds like we are going out on a limb as a country. But you got to worry where we'll be if we rush out first jabs and mess it up. It's all well and good crowing about charts where we are well ahead of vaccinating people if we get it wrong and waste it. Better surely to stick to the tested manufacturers tests

It’s not like Boris has unilaterally made this decision a whim.

Andrew Pollard, the head of the Oxford Vaccine Group and chief investigator into the trial of this vaccine, said that extending the gap between vaccines made biological sense. “Generally, a longer gap between vaccine doses leads to a better immune response, with the second dose causing a better boost. (With HPV vaccine for girls, for example, the gap is a year and gives better responses than a one month gap.) From the Oxford vaccine trials, there is 70% protection after the first dose up to the second dose, and the immune response was about three times greater after the second dose when the second dose was delayed, comparing second dose after four weeks versus second dose after 2-3 months,” he told The BMJ, referring to the MHRA’s summary of product characteristics.11

“With the Pfizer vaccine, there are no published data comparing shorter and longer gaps between doses because all participants had the second dose at 3-4 weeks. However, the biology is straightforward and will be the same as with all vaccines . . . The immune system remembers the first dose and will respond whether the later dose is at three weeks or three months.”

In a statement the British Society for Immunology said, “Most immunologists would agree that delaying a second ‘booster’ dose of a protein antigen vaccine (such as the two approved covid-19 vaccines) by eight weeks would be unlikely to have a negative effect on the overall immune response post-boost. We also would not expect any specific safety issues to arise for the individual due to delaying the second dose, other than an increased potential risk of disease during the extended period due to lowered protection.”

I dont think he did and there is certainly science behind it. But my worry is we are the only country/science doing it, coupled with Israel saying the vaccine efficiency as far as they have found thus far is below the effectiveness claimed by Pfizer. Especially after 1 dose.

I've read some other countries are considering spacing out the vaccine but I think we are the only ones actually doing it currently. Thats my concern, when your the only one doing it that suggests there's a bit of a gamble to it

[Skub]

It's Portimao that's my thoughts as you can imagine. Be great if the UK does well with vaccination, but sod all use to me if Portugal is a shit show along with south America as we won't be allowed to fly there

There may be an additional consideration,even if you are allowed within the regulations to fly to Portugal,will you wish to take the risk,if it's not 100% safe?

[irie]

Andrew Pollard, the head of the Oxford Vaccine Group and chief investigator into the trial of this vaccine, said that extending the gap between vaccines made biological sense. “Generally, a longer gap between vaccine doses leads to a better immune response, with the second dose causing a better boost. (With HPV vaccine for girls, for example, the gap is a year and gives better responses than a one month gap.) From the Oxford vaccine trials, there is 70% protection after the first dose up to the second dose, and the immune response was about three times greater after the second dose when the second dose was delayed, comparing second dose after four weeks versus second dose after 2-3 months,” he told The BMJ, referring to the MHRA’s summary of product characteristics.

Exactly.

The optimal gap between Covid-19 vaccine doses to provide maximum immunity can not be established during trials for the obvious reason that trials might have to continue for many months, if not years.

[Yorick]

It's Portimao that's my thoughts as you can imagine. Be great if the UK does well with vaccination, but sod all use to me if Portugal is a shit show along with south America as we won't be allowed to fly there

There may be an additional consideration,even if you are allowed within the regulations to fly to Portugal,will you wish to take the risk,if it's not 100% safe?

I'm not going if I don't feel safe. I've gotta spend 36 hours on a ferry.

[Wreckless Rat]

That really doesn't sound good.

Neither does extending the gap between doses, sounds like we are going out on a limb as a country. But you got to worry where we'll be if we rush out first jabs and mess it up. It's all well and good crowing about charts where we are well ahead of vaccinating people if we get it wrong and waste it. Better surely to stick to the tested manufacturers tests

It’s not like Boris has unilaterally made this decision a whim.

Andrew Pollard, the head of the Oxford Vaccine Group and chief investigator into the trial of this vaccine, said that extending the gap between vaccines made biological sense. “Generally, a longer gap between vaccine doses leads to a better immune response, with the second dose causing a better boost. (With HPV vaccine for girls, for example, the gap is a year and gives better responses than a one month gap.) From the Oxford vaccine trials, there is 70% protection after the first dose up to the second dose, and the immune response was about three times greater after the second dose when the second dose was delayed, comparing second dose after four weeks versus second dose after 2-3 months,” he told The BMJ, referring to the MHRA’s summary of product characteristics.11

“With the Pfizer vaccine, there are no published data comparing shorter and longer gaps between doses because all participants had the second dose at 3-4 weeks. However, the biology is straightforward and will be the same as with all vaccines . . . The immune system remembers the first dose and will respond whether the later dose is at three weeks or three months.”

In a statement the British Society for Immunology said, “Most immunologists would agree that delaying a second ‘booster’ dose of a protein antigen vaccine (such as the two approved covid-19 vaccines) by eight weeks would be unlikely to have a negative effect on the overall immune response post-boost. We also would not expect any specific safety issues to arise for the individual due to delaying the second dose, other than an increased potential risk of disease during the extended period due to lowered protection.”

I dont think he did and there is certainly science behind it. But my worry is we are the only country/science doing it, coupled with Israel saying the vaccine efficiency as far as they have found thus far is below the effectiveness claimed by Pfizer. Especially after 1 dose.

I've read some other countries are considering spacing out the vaccine but I think we are the only ones actually doing it currently. Thats my concern, when your the only one doing it that suggests there's a bit of a gamble to it

There’s a bit of a gamble with the entire vaccine program, despite being “safe” show me one other vaccine that has gone from concept to delivery in under a year. And while Pfizer want to piss and moan, they aren’t moaning about the super compressed testing regime, the removal of barriers to market, while making billions in profit from it all.

Most ( perhaps all) other vaccines this delay increases the immunity given, they also have no idea how long the vaccine lasts even given at the tested spacing, not banging the drum about that though are they?

[weeksy]

It's Portimao that's my thoughts as you can imagine. Be great if the UK does well with vaccination, but sod all use to me if Portugal is a shit show along with south America as we won't be allowed to fly there

There may be an additional consideration,even if you are allowed within the regulations to fly to Portugal,will you wish to take the risk,if it's not 100% safe?

Of course fella... of course. But that one is very much open to debate between myself and Mrs Weeksy at the moment. At this moment in time if it were next week, i'd say no. However, it's not till the 27th May so we'll be very much playing it by ear from the end of March when we have to pay the remainder of our money, or pull the plug and lose £600. In some ways, the government could make our life easier if they cancel flights etc as that would facilitate a refund on both our flights (which we can transfer to some other dates) and on our tracktime/holiday.

[Wreckless Rat]

Will be interesting once the uk is vaccinated - and France is still trying to bumble its way out of its current situation of doing fuck all, and having a population who don’t trust their Drs enough to take the vaccine, whether the UK will have the balls to return the favour and ban all French from the UK without a test + isolation etc. I do hope so.

It's Portimao that's my thoughts as you can imagine. Be great if the UK does well with vaccination, but sod all use to me if Portugal is a shit show along with south America as we won't be allowed to fly there

Forgive me for not knowing but why do you need to travel to either of those places?