Pfizer vaccine approved
- Taipan
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Re: Pfizer vaccine approved
Govt has delayed second (Pfizer) jab to 12 weeks, so more people can be vaccinated, but WHO says second jab should be within 6 weeks maximum and no data is available for longer periods? Is this a gamble to assume it'll still work okay?
Considerations for deferring the second dose
WHO acknowledges that a number of countries face exceptional circumstances of vaccine supply constraints combined with a high
disease burden. Some countries have therefore considered delaying the administration of the second dose to allow for a higher initial
coverage. This is based on the observation that efficacy has been shown to start from day 12 after the first dose and reached about
89% between days 14 and 21, at the time when the second dose was given. No data on longer term efficacy for a single dose of the
mRNA vaccine BNT162b2 currently exist, as the trial participants received 2 doses with an interval between doses in the trial
ranging from 19 to 42 days. Of note, neutralizing antibody responses are modest after the first dose and increase substantially after
the second dose.
Countries experiencing exceptional epidemiological circumstances may consider delaying for a short period the administration of
the second dose as a pragmatic approach to maximizing the number of individuals benefiting from a first dose while vaccine supply
continues to increase. WHO’s recommendation at present is that the interval between doses may be extended up to 42 days (6
weeks), on the basis of currently available clinical trial data. Should additional data become available on longer intervals between
doses, revision of this recommendation will be considered. Countries should ensure that any such programme adjustments to dose
intervals do not affect the likelihood of receiving the second dose.
Taken from; Interim recommendations for use of the Pfizer–BioNTech COVID-19 vaccine, BNT162b2, under Emergency Use Listing
8 January 2021| Publication
https://www.who.int/publications/i/item ... 2b2-2021.1
Considerations for deferring the second dose
WHO acknowledges that a number of countries face exceptional circumstances of vaccine supply constraints combined with a high
disease burden. Some countries have therefore considered delaying the administration of the second dose to allow for a higher initial
coverage. This is based on the observation that efficacy has been shown to start from day 12 after the first dose and reached about
89% between days 14 and 21, at the time when the second dose was given. No data on longer term efficacy for a single dose of the
mRNA vaccine BNT162b2 currently exist, as the trial participants received 2 doses with an interval between doses in the trial
ranging from 19 to 42 days. Of note, neutralizing antibody responses are modest after the first dose and increase substantially after
the second dose.
Countries experiencing exceptional epidemiological circumstances may consider delaying for a short period the administration of
the second dose as a pragmatic approach to maximizing the number of individuals benefiting from a first dose while vaccine supply
continues to increase. WHO’s recommendation at present is that the interval between doses may be extended up to 42 days (6
weeks), on the basis of currently available clinical trial data. Should additional data become available on longer intervals between
doses, revision of this recommendation will be considered. Countries should ensure that any such programme adjustments to dose
intervals do not affect the likelihood of receiving the second dose.
Taken from; Interim recommendations for use of the Pfizer–BioNTech COVID-19 vaccine, BNT162b2, under Emergency Use Listing
8 January 2021| Publication
https://www.who.int/publications/i/item ... 2b2-2021.1
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- Skub
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Re: Pfizer vaccine approved
These masks are growing on me.
"Be kind to past versions of yourself that didn't know what you know now."
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https://soundcloud.com/skub1955
Walt Whitman
https://soundcloud.com/skub1955
- Horse
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- Skub
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Re: Pfizer vaccine approved
Like balm for the eyes,in this case!
"Be kind to past versions of yourself that didn't know what you know now."
Walt Whitman
https://soundcloud.com/skub1955
Walt Whitman
https://soundcloud.com/skub1955
- Taipan
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Re: Pfizer vaccine approved
10. I’ve read your WHO piece above. The general consensus is; it’s better to get the first dose out to as many as possible now. I will be much safer having one dose ( anything >50% is really good from a vaccine perspective) and I’d rather more people got at least the first dose than more people experienced being proned in icu.
It’s also really questionable whether the 6, 10, 12 week wait is valid with regards to absolute efficacious modality.
It’s also really questionable whether the 6, 10, 12 week wait is valid with regards to absolute efficacious modality.
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Re: Pfizer vaccine approved
Plus it’s what’s available and I need to go back in the wards and this new variant doesn’t fuck about
- Taipan
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Re: Pfizer vaccine approved
Docca wrote: ↑Mon Jan 18, 2021 8:56 pm 10. I’ve read your WHO piece above. The general consensus is; it’s better to get the first dose out to as many as possible now. I will be much safer having one dose ( anything >50% is really good from a vaccine perspective) and I’d rather more people got at least the first dose than more people experienced being proned in icu.
It’s also really questionable whether the 6, 10, 12 week wait is valid with regards to absolute efficacious modality.
Cheers for the reply. If its good enough for you in your role, it'll hopefully allay my In-Laws fears. Lots of fear mongering about today, focusing on it'll be useless after 6 weeks and 0.01seconds etc.
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Re: Pfizer vaccine approved
So ‘lulz’ but I feel dreadful today. This is to be expected and welcomed as my body is doing its thing. Apparently going to be like this for a couple of days.
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- Horse
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Re: Pfizer vaccine approved
He won't answer honestly if Bill Gates is in control.Wreckless Rat wrote: ↑Tue Jan 19, 2021 10:44 amAny signs of new limbs, extra head, multiple penises etc?
Even bland can be a type of character
- ogri
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Re: Pfizer vaccine approved
Everything still attached and no new additions
Ignorance is bliss
- ZRX61
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Re: Pfizer vaccine approved
Moderna vaccinations on hold here owing to one batch sending a bunch of people to the hospital with some kind of reaction.
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Re: Pfizer vaccine approved
Even if the vaccine isn't perfect I suspect it's less likely to fuck you in the arse than long covid (or regular covid for the TE).
To a kid looking up to me, life ain't nothing but bitches and money.
- DefTrap
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Re: Pfizer vaccine approved
A friend was tasked with taking some olds to their booked vaccine appt (one of the Norwich hubs is out in the sticks). It was near the end of the day and they had some vaccine over, lucky young'un got hers early.
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Re: Pfizer vaccine approved
What if she can't get the second dose for ages and that somehow banjaxes it?
Then Covid could come and get her, very much like House of Pain.
She should have pushed over a few TEs and grabbed a second dose.
To a kid looking up to me, life ain't nothing but bitches and money.
- DefTrap
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Re: Pfizer vaccine approved
If I were nearer I'd be offering to take these olds until I'd had my two. Then the rest I'd off on gumtree.Asian Boss wrote: ↑Tue Jan 19, 2021 9:00 pmWhat if she can't get the second dose for ages and that somehow banjaxes it?
Then Covid could come and get her, very much like House of Pain.
She should have pushed over a few TEs and grabbed a second dose.