Astrazeneca/Oxford vaccine approved

[weeksy]

Just got this from my cousin's duaghter...

David has been taken in to hospital. After his vaccine 2 weeks ago he became ill on Saturday and was taken to hospital. He has something called gullien barre syndrome. He has lost all feeling in legs and arms. He was rushed down to intensive care yesterday morning and is now unconscious and on a ventilator as he has a bad chest infection.

He's obviously an unlucky one, only 58.

He still can't move his limbs after 4 months, and we got this message yesterday..

David’s heart stopped the other night and they had to perform CPR to get him back. He now has a collapsed lung and also pneumonia after mucus build up from having the breathing tube in.

He's having a fucking tough time

That seems an understatement. Sad for him and family

[Yorick]

Just got this from my cousin's duaghter...



He's obviously an unlucky one, only 58.

He still can't move his limbs after 4 months, and we got this message yesterday..

David’s heart stopped the other night and they had to perform CPR to get him back. He now has a collapsed lung and also pneumonia after mucus build up from having the breathing tube in.

He's having a fucking tough time

That seems an understatement. Sad for him and family

His daughter can only go see him for half hour each day now

We get regular updates. Usually the same news.

But he was able to watch all the Euros.
I keep sending crap jokes. They get read, but no reply. No probs.

[Yorick]

IMG-20210728-WA0001.jpg (49.18 KiB) Viewed 358 times

[DefTrap]

https://www.cnbc.com/2021/08/10/covid-v ... 1628567601

My take on it is that it's a question of tough shit. You don't get to have 'equal rights' based upon a completely unqualified sense of it just being a bit unfair. I have to say I feel a bit sorry for those who genuinely can't be vaccinated or for whom it's less effective. But that's not what this is about. This is about idiots.

Are there really so many folk around who think? -
- "Testing has been rushed." Well, it hasn't. Independent bodies have verified the safety and efficacy - but apparently you know better? As the months tick on and there is no credible evidence that (even if this was the case, which it is not) that any of the bagful of covid vaccines does you any harm - wouldn't you change your mind? Because of evidence? But then you're the sort of person who probably believes the vaccine has magnets and microchips in it anyway, so ...
- "I'm not going to have anything the government is 'forcing' me to do" - nobody is forcing you but the rest of us have had enough of waiting for you to stop being childish about it. You're fecking privileged to have a choice FFS - many, many countries won't have widespread vaccination programs for some time yet. So - vaccine passports - yep, fair enough.

[Yorick]

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[JamJar]

Did you see the antivaxxers that stormed the BBC but went to their old building? I was surprised because normally they research things so thoroughly

[irie]

Did you see the antivaxxers that stormed the BBC but went to their old building? I was surprised because normally they research things so thoroughly

I think the BBC left about 8 years ago and the building is now used by ITV for chat shows and other mindless shit.

[Saga Lout]

Are there really so many folk around who think? -
- "Testing has been rushed."

<snip>

Sticks up hand.

If the testing hasn't been rushed, why do other vaccines not get tested and approved in a year or less? Why does it take them 5, 10, even 15 years?
If the testing hasn't been rushed, why do these vaccines/gene therapies only have emergency approval?
What will happen once the emergency is declared to be over and the emergency approval lapses?
Or is the emergency going to be permanent?

[wheelnut]

Are there really so many folk around who think? -
- "Testing has been rushed."

<snip>

Sticks up hand.

If the testing hasn't been rushed, why do other vaccines not get tested and approved in a year or less? Why does it take them 5, 10, even 15 years?
If the testing hasn't been rushed, why do these vaccines/gene therapies only have emergency approval?
What will happen once the emergency is declared to be over and the emergency approval lapses?
Or is the emergency going to be permanent?

Well there’s the better part of 5 billion vaccines been administered over the last year. That a fairly good test.

[weeksy]

Are there really so many folk around who think? -
- "Testing has been rushed."

<snip>

Sticks up hand.

If the testing hasn't been rushed, why do other vaccines not get tested and approved in a year or less? Why does it take them 5, 10, even 15 years?
If the testing hasn't been rushed, why do these vaccines/gene therapies only have emergency approval?
What will happen once the emergency is declared to be over and the emergency approval lapses?
Or is the emergency going to be permanent?

There's a difference between rushed and 'put first in the queue'

There may be 50,000 vaccines generally that need testing, so it takes a long time because there's already 49,999 ahead of you that need signing off, agreeing, discussing.

The CV19s have gone straight in from test to "yes/no" without anything else being put in front of them

[irie]

Are there really so many folk around who think? -
- "Testing has been rushed."

<snip>

Sticks up hand.

If the testing hasn't been rushed, why do other vaccines not get tested and approved in a year or less? Why does it take them 5, 10, even 15 years?
If the testing hasn't been rushed, why do these vaccines/gene therapies only have emergency approval?
What will happen once the emergency is declared to be over and the emergency approval lapses?
Or is the emergency going to be permanent?

Putting it simply, (a) the vaccines were required as a response to a global emergency, and (b) technological progress* is non-linear which after vaccine development enables the rapid development of new testing regimes.

* for example look at the initial rapid genomic sequencing of SARS-CoV-2

[Horse]

Posted here, as good as anywhere.

Any example of how it's [not] "just like flu".

https://www.bbc.co.uk/news/world-asia-india-58066767

Last September, Vipul Shah spent 11 days in critical care battling Covid-19 in a hospital in Mumbai.

Mr Shah, who had no previous history of diabetes, was administered steroids which are used to treat the coronavirus infection.

Steroids reduce inflammation in the lungs for Covid-19 and appear to help stop some of the damage that can happen when the body's immune system goes into overdrive to fight off the virus.

But they also reduce immunity and push up blood sugar levels in both diabetic and non-diabetic Covid-19 patients.

Nearly a year after recovery, Mr Shah, 47, is still on medication to control his blood sugar.

Covid and diabetes: My story
"I know a lot of people like me who are taking medicines for diabetes after recovering from Covid-19," Mr Shah, a stock trader, said.

India accounts for one in six people in the world with diabetes. Home to an estimated 77 million diabetics, it is second only to China, which has 116 million people living with the disease.

Doctors reckon millions more remain undiagnosed for this chronic and progressive disease which occurs when the pancreas doesn't produce enough insulin or the body is unable to effectively use the insulin it produces.

This leads to increased concentration of glucose - a type of sugar - in the blood and poses serious health risks, including damage to the kidneys, eyes and heart.

Diabetes is among a group of underlying conditions which put people at increased risk of severe Covid-19 disease. The others are obesity, high blood pressure, and heart and lung diseases.

Now physicians fear a large number of patients who have recovered from Covid-19 are at risk of newly diagnosed, full-blown diabetes. With nearly 32 million recorded infections, India has the second-largest Covid-19 caseload in the world, behind the US.

Type 1 diabetes and Covid-19 link being investigated
"The worry is that Covid-19 could trigger a tsunami of diabetes in India after the pandemic is over," Dr Rahul Baxi, a Mumbai-based diabetologist, told me.

He said 8-10% of his patients with no history of diabetes who contracted Covid-19 continued to have high sugar levels months after recovery and were on medication.

"Some have borderline diabetes. Others are managing with medicines even a year after recovery," he said.

Doctors around the world are debating whether Covid-19 itself is causing diabetes in patients with no previous history.

This, they say, could be due to the use of steroids in treatment; the cytokine storm when the body's immune system goes into overdrive to fight off the coronavirus; and the virus itself injuring the cells in the pancreas which make insulin.

[Saga Lout]

Are there really so many folk around who think? -
- "Testing has been rushed."

<snip>

Sticks up hand.

If the testing hasn't been rushed, why do other vaccines not get tested and approved in a year or less? Why does it take them 5, 10, even 15 years?
If the testing hasn't been rushed, why do these vaccines/gene therapies only have emergency approval?
What will happen once the emergency is declared to be over and the emergency approval lapses?
Or is the emergency going to be permanent?

Well there’s the better part of 5 billion vaccines been administered over the last year. That a fairly good test.

And obviously the, so far unknown, long term adverse effects don't matter?

There's no way to gain 5 years worth of data about five years worth of adverse effects in one year.

Just to be clear: I've had the vaccine. I'm 72 years old, I reckon the virus is probably more dangerous to me than the vaccine, but if I were 40 and in the rude good health I enjoyed when I was 40 I'd probably decline it and if I had school age kids I'd definitely decline it for them.

[DefTrap]

Sticks up hand.

If the testing hasn't been rushed, why do other vaccines not get tested and approved in a year or less? Why does it take them 5, 10, even 15 years?
If the testing hasn't been rushed, why do these vaccines/gene therapies only have emergency approval?
What will happen once the emergency is declared to be over and the emergency approval lapses?
Or is the emergency going to be permanent?

I'm probably wasting breath but

Prioritised, rather than rushed. Front of the queue, taking precedence, unprecedented collaboration. And there's been a certain amount of luck and an enormous amount of skill involved - getting so many vaccines showing such high efficacy is fecking miraculous. You might say that covid19 is very similar to SARS and MERS and you might have a point, a good head start at least, certainly it would help to shorten the lead time.

Amazing what you can do if you really want to. Some would say the current regulations for drug approval are too strict. Maybe.

The priority part is at least part of the reason the FDA is saying these drugs are approved as EUA, they have to follow their own rules as much as the rest of us. If they want to deviate, they have to say how and why and assess the risks. In this case the risks also include prioritising covid vaccines to the detriment of other drugs in the approval system. The risk assessment takes account of all deviations from the standard and sets out mitigations - it had to be plausible, it can't just be bollocks.

If you want to whinge that there wasn't time to observe side effects of vaccines in many people on approval, especially across the entire demography of ages and races, then yeah, however that ship has now well and truly sailed with the subsequent rollout. To do this thoroughly, to have an answer for every question could easily take a long time. To be honest that would never really happens anyway, it's too costly, but there might be more testing, if there were findings. Side effects are standardly monitored post approval anyway, so there's no massive difference there, if anything there's more monitoring and scrutiny.

The emergency approvals won't be permanent, unless the emergency turns out to be permanent. Then I imagine at some point it won't be deemed an emergency any more.

[gremlin]

IIRC, there was a similar situation with an Ebola outbreak in Africa a few years back.

https://www.bbc.com/news/world-africa-38414060

"Now, two years later, we have a vaccine. It usually takes around 10 years."

Two years? Fucking tardy bastards.



(Turns out common sense prevailing isn't such new thing after all. How disappointing for the conspiracy theorists)

[Mr. Dazzle]

No one GAS if all the restaurants and package holidays in West Africa have to shut down. That's why it took longer.

[gremlin]

No one GAS if all the restaurants and package holidays in West Africa have to shut down. That's why it took longer.

To quote Nick Nolte's character in the film Hotel Rwanda, explaining why no aid was coming from the supposedly civilised world, "You're not even a nigger. You're an African."

I think whoever wrote that line in the script summed up the state of the world quite succinctly.

[Yorick]

Just got this from my cousin's duaghter...

David has been taken in to hospital. After his vaccine 2 weeks ago he became ill on Saturday and was taken to hospital. He has something called gullien barre syndrome. He has lost all feeling in legs and arms. He was rushed down to intensive care yesterday morning and is now unconscious and on a ventilator as he has a bad chest infection.

He's obviously an unlucky one, only 58.

Nearly a year later and he's just starting to recover. Paralysed for 10 months.
Found some movement end of last year. Can sit in a chair now.

Today I got this message



I can't search on this device, I have to get a nurse to do it or wait for Hannah to visit. I operate this with my head, there is a little camera sitting on top of the screen and a micro dot stuck on the frame of my glasses and it turns my head into a cursor, I move my head to scroll down etc. so it has limited use and as I have no movement in my hands, it is impressive that I am trying this with my head. it also speaks the words for me so I can communicate with people but I have had my trachy removed this morning so I can now speak unaided for the first time in 11 months. I

[Yorick]

We're a piss taking lot and me and his brother are debating how soon we can start the Stephen Hawkins jokes. He'd have done it to us by now

[Horse]

We're a piss taking lot and me and his brother are debating how soon we can start the Stephen Hawkins jokes. He'd have done it to us by now

Like "Do you want diesel?"